Tsanangudzo Pfupi
Nhamba yeCAS: 54965-21-8
Molecular formula: C12H15N3O2S
molecular uremu: 265.333
Kemikari chimiro:
Tsanangudzo
Albendazole (ALBENZA) inopihwa nemuromo yakakura-spectrum anthelmintic. Albendazole chewable tablet inosanganisirwa muWorld Health Organisation (WHO) rondedzero yemishonga yakakosha semudumbu anthelminthic uye antifilarial mushonga. Albendazole piritsi rakagadzirwa neSmithKline Animal Health Laboratories uye rakatenderwa neUS Food and Drug Administration (FDA) muna 1996.
Albendazole ine simba rekuuraya zvachose mazai echikwapu uye hookworm pamwe nekuuraya zvishoma mazai eAscaris; inogona zvakare kubvisa marudzi akasiyana eematodes parasitizing mukati memiviri yemhuka, uye ine zvinokonzeresa pakubvisa kana kuuraya zvakananga tapeworms necysticercci. Saka inobatsira pakurapa hydatid uye nervous system (cysticercosis) inokonzerwa nehutachiona hwehonye yenguruve, uyewo mukurapa hookworm, roundworm, pinworm, nematode trichinella, tapeworm, whipworm uye stercoralis nematode.
Pharmacodynamics
Albendazole imhando yezvigadzirwa zvebenzimidazole. Inokurumidza kugadzirwa mu vivo mu sulfoxide, sulfone uye 2-polyamine sulfone doro. Iyo inogona kusarudza uye isingachinjiki kudzvanya kubatwa kweglucose ye intestinal nematodes, zvichikonzera kupera kwe endogenous glycogen yehonye; panguva imwecheteyo, inodzivisawo basa re fumarate reductase, uye nokudaro kudzivirira chizvarwa cheadenosine triphosphate, pakupedzisira chinokonzera rufu rwezvipembenene.
Kufanana nemebendazole, kuburikidza nekukonzera kusvibiswa kwe cytoplasmic microtubules ye intestinal parasites uye kusunga kune tubulin, inokonzera kuvhara kwekutakura kwemukati, zvichiita kuti kuunganidza kweGolgi endocrine particles; cytoplasm inowedzera kunyungudika zvishoma nezvishoma, zvichikonzera kufa kwekupedzisira kwezvipembenene.
Ichi chigadzirwa chinogona kuuraya zvachose mazai hookworm, mazai epini, mazai emvere dzemakwai, tapeworm mazai uye cysticercosis tyava mazai uye kuuraya zvishoma mazai eAscaris.
Common Use
Albendazole mushonga unoshandiswa kurapa zvirwere zvinokonzerwa nemaparasite. Inogona kupihwa kurapa isingawanzo hutachiona hwehuropi (neurocysticercosis) kana inogona kupihwa kurapa hutachiona hunokonzera manyoka akakosha (microsporidiosis).
Clinical Kushandisa
Albendazole ine huwandu hwakawanda hwekuita kurwisa intestinal nematodes uye cestodes, pamwe nezviropa zvechiropa Opisthorchis sinensis, Opisthorchis viverrini, uye Clonorchis sinensis. Iyo zvakare yakashandiswa zvinobudirira kurwisa Giardia lamblia. Inoshandiswa zvakanyanya pasi rose pakurapa intestinalnematode infection. Inoshanda semushonga mumwe chete wekurapa ascariasis, New and Old World hookworm zvirwere, uye trichuriasis. Multiple-dose therapy nealbendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, uye hydatid chirwere. Kushanda kwealbendazole kurwisa tapeworms (cestodes) kunowanzo kushanduka uye kusatarisisa. Inoshandawo mukurapa cerebral uye spinal neurocysticercosis, kunyanya kana ikapiwa nedexamethasone.Albendazole inokurudzirwa kurapwa kwegnathostomiasis.
