Tsanangudzo Pfupi
Nhamba yeCAS:472-15-1
Molecular formula:C30H48O3
molecular uremu:456.71
Kemikari chimiro:
| Basic Information | |
| Product name | Betulinic acid |
| Giredhi | Pharma giredhi |
| Chitarisiko | Muchena kana chena-chena |
| Assay | 98% |
| Sherufu hupenyu | 2 years |
| Packing | 25kg / chigubhu |
| Condition | Yakagadzikana, asi chengetedza inotonhorera. Izvo zvisingaenderani neakasimba oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium mavitamini. |
Tsanangudzo
Betulinic acid (472-15-1) imhando yeLupane triterpenoid kubva kuwhite birch tree (Betula pubescens). Inokonzera apoptosis mumhando dzakasiyana-siyana dzemasero.1 Inoita kuti mitochondrial permeability transition pore opening.2 ?Inoita sechemosensitizer yemishonga inorwisa cancer mishonga muchemoresistant colon cancer cell lines.3 Cell permeable.
Shandisa
Betulinic Acid ndeye yakasikwa pentacyclic triterpenoid. Betulinic Acid inoratidza anti-inflammatory uye anti-HIV chiitiko. Betulinic Acid inosarudza inokonzera apoptosis mumasero emamota kuburikidza nekuita zvakananga mitochondrial nzira yeapoptosis kuburikidza nep53- uye CD95-yakazvimirira maitiro. Betulinic Acid inoratidzawo TGR5 agonist chiitiko.
Betulinic acid (BetA) yakashandiswa:
1.kuedza maitiro ayo seantiviral agent kurwisa Dengue virus (DENV).
2.as a sterol regulatory element-binding protein (SREBP) inhibitor kudzvinyirira lipid metabolism uye kupararira kwemasero akajeka erenal cell carcinoma (ccRCC).
3.semushonga wekuyedza anti-bundu zvimiro zve cell viability uye apoptotic cell death assays mune akawanda myeloma modhi.
Anticancer Research
Mushonga uyu ndeye pentacyclic triterpene inowanikwa kubva kuBetula neZizyphus mhando, iyo inoratidza yakasarudzika cytotoxicity kurwisa melanoma masero (Shoeb2006). Inogadzira reactive okisijeni marudzi, activates MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-kukura transcriptionalactivators, modulates basa aminopeptidase-N, uye nokudaro inducesapoptosis mukenza masero (Desai et al. 2008; Fulda 2008).
Biological Activity
Natural triterpenoid inoratidza anti-HIV uye antitumor chiitiko. Inokurudzira kugadzirwa kweiyo reactive oxygen marudzi (ROS) uye inomutsa NF- κ B. Inoratidza TRG5 agonist basa (EC 50 = 1.04 μ M).
Biochem/physiol Zviito
Betulinic acid, pentacyclic triterpene, inosarudza apoptosis mumasero ebundu nekuita zvakananga mitochondrial nzira yeapoptosis kuburikidza nep53- uye CD95-yakazvimirira maitiro.
