Tsanangudzo Pfupi
Nhamba yeCAS: 27164-46-1
Molecular formula: C14H15N8NaO4S3
molecular uremu: 478.5
Kemikari chimiro:
| Basic Information | |
| Product name | Cefazolin sodium munyu |
| CAS Nha. | 27164-46-1 |
| Chitarisiko | Ichena kusvika kuOff-White crystalline poda |
| Giredhi | Pharma Grade |
| Storage | Ramba munzvimbo ine rima, inert atmosphere, 2-8°C |
| Sherufu Hupenyu | 2 years |
| Kugadzikana | Yakagadzikana, asi inogona kunge ichipisa - chengetedza munzvimbo inotonhorera. Inogona kuchinja ruvara payakavhenekerwa - chengeta murima. Hazvienderani neakasimba oxidizing agents. |
| Package | 25kg/Drum |
Product Description
A semi synthetic antibiotic ine cephalosporins mumorekuru we cephalosporins. Yakashandurwa se Xianfeng mycin. ndezva β-Lactam antibiotics, hongu β- Izvo zvinobva pa7-aminocephalosporanic acid (7-ACA) mu lactam mishonga inorwisa mabhakitiriya ine nzira dzakafanana dzehutachiona. Mhando yemishonga iyi inogona kuparadza sero rusvingo rwebhakitiriya uye kuvauraya panguva yekubereka. Iine simba rakasimba rekusarudza pabhakitiriya uye rinenge risina chepfu kuvanhu, ine zvakanakira senge yakafara antibacterial spectrum, yakasimba antibacterial mhedzisiro, kuramba kune penicillin enzymes, uye kushoma allergiki maitiro kana achienzaniswa nepenicillin. Saka iyo yakakosha mishonga inorwisa mabhakitiriya ine hunyanzvi hwepamusoro, yakaderera muchetura, uye yakafara kiriniki application. Chizvarwa chekutanga cephalosporins chakagadzirwa kare, iine yakasimba antibacterial chiitiko kana ichienzaniswa neChemicalbook, yakamanikana antibacterial spectrum, uye zvirinani anti Gram positive bacteria mhedzisiro pane Gram negative bacteria. Yakagadzirwa neStaphylococcus aureus β- Lactamase yakagadzikana uye inogona kutadzisa kugadzirwa kweutachiona husina kunaka β- Lactamases haina kugadzikana uye ichiri kugadzirwa neGram negative bacteria yakawanda β- Yakakuvadzwa nelactamases. Cefazolin sodium inonzi semi synthetic chizvarwa chekutanga cephalosporin ine antibacterial mhedzisiro kurwisa mabhakitiriya egiremu uye giremu-negative. Inowanzoshandiswa muzvirwere zvekufema, urogenital system, ganda rakapfava, pfupa uye majoini, uye bhiriary turakiti inokonzerwa nehutachiona hwehutachiona, pamwe ne endocarditis, sepsis, pharyngeal uye zvirwere zvenzeve. Iine basa rakasimba rinopikisa giramu-positive mabhakitiriya akadai seStaphylococcus aureus uye Streptococcus (kunze kweEnterococcus), uye yakakwirira kune yechipiri Chechitatu chizvarwa cephalosporins.
Kushandisa Kemikari
Cefazolin (Ancef, Kefzol) imwe yenhevedzano ye semisyntheticcephalosporins umo C-3 acetoxy function yakatsiviwa ne thiol-containing heterocycle-pano, 5-methyl-2-thio-1,3,4-thiadiazole. Iyo ine zvakare yakasarudzika tetrazolylacetyl acylating boka. Cefazolin yakabudiswa muna 1973 semvura inonyungudika sodium munyu. Inoshanda chete ne parenteral administration.
Cefazolin inopa yakakwira serum mazinga, inononoka renalclearance, uye yakareba hafu yeupenyu kupfuura mamwe ekutanga-generationcephalosporins. Inenge 75% mapuroteni akasungwa muplasma, kukosha kwepamusoro kudarika mamwe akawanda cephalosporins.Kutanga mu vitro uye kliniki zvidzidzo zvinoratidza kuti cefazolin inoshanda zvakanyanya kurwisa Gram-negative bacilli asi isinganyanyi kushanda kune Gram-positive cocci kupfuura chero cephalothin orcephaloridine. Kuitika kwehuwandu hwe thrombophlebitis inotevera jekiseni remutsinga uye kurwadziwa panzvimbo yejekiseni ye intramuscularijection inoratidzika kuva yakaderera pane parenteralcephalosporins.
