Tsanangudzo Pfupi
Nhamba yeCAS: 38821-53-3
Molecular formula: C16H19N3O4S
molecular uremu: 349.4
Kemikari chimiro:
| Basic Information | |
| Product name | Cefradine |
| Kugadzikana | Chiedza Sensitive |
| Chitarisiko | Upfu chena |
| Assay | 99% |
| Melting point | 140-142 C |
| Packing | 5KG;1KG |
| Boiling point | 898℃ |
Tsanangudzo
Cefradine (inozivikanwawo se cephradine), 7- [D-2-amino-2 (1,4cyclohexadien1-yl) acetamido] -3-methyl-8-0x0-5thia-l-azabicyclo[4.2.0] oct-2- ene-2-carboxylic acid monohydrate (111 is semi-synthetic cephalosporin antibiotic. inoshandiswa nemuromo, intramuscularly, uye intravenously. Mamiriro ecephradine akafanana nea Cephalexin, mutsauko chete uri murin'i ine nhengo nhanhatu. Cephalexin ine nhatu nhatu. zvisungo zviviri zvinogadzira inonhuhwirira system nepo cephradine ine maviri maviri mabhondi mumhete imwe chete[1].
Mufananidzo1 chimiro chemakemikari checefradine;
Cephradine inonzi white crystalline powder ine molecular weight ye 349.4[2]. Iyo synthesis ye cephradine yakakurukurwa[3]. Cephradine inonyungudika zvakasununguka mu aqueous solvents. Iyo zwitterion, ine zvese alkaline amino boka uye ane acidic carboxyl boka. Mune pH renji ye3-7, cephradine iripo semunyu wemukati[4]. Cephradine yakagadzikana kwe 24 hr pa 25" mukati me pH range ye 2-8. Sezvo yakagadzikana mune acidic media, pane kurasikirwa kushoma kwekuita mugastric fluid; kurasikirwa kwepasi pe7% kwakataurwa.[5].
Cephradine haina kusimba yakasungwa kumapuroteni emunhu serum. Mushonga wacho wakanga uri pasi pe20% wakasungwa kumapuroteni eSerum[4]. Pane serum concentration ye10-12 pg/ml, 6% yemishonga yose yakanga iri muprotein-bound complex. Chimwe chidzidzo[6]akawana kuti pahuwandu hwehuwandu hwe10 pg / ml, 28% yemishonga yakanga iri muprotein-bound state; pahuwandu hwehuwandu hwe100 pg / ml, 30% yemishonga yakanga iri muprotein-bound state. Ichi chidzidzo chakaratidzawo kuti kuwedzerwa kweserum kune cephradine kwakaderedza antibiotic basa. Chimwe chidzidzo[2]yakaratidza kuti mapuroteni anosunga cephradine akasiyana kubva pa8 kusvika ku20%, zvichienderana nekuwanda kwemushonga. Nekudaro, chidzidzo chakaitwa naGadebusch et al.[5]haina kuwana shanduko muMIC ye cephradine kune Staphylococcus aureus kana Escherichia coli mushure mekuwedzera kweserum yevanhu.
Zviratidzo
Cephradine inoshanda mu vitro inopesana nehupamhi hwehutachiona hwe gram-positive uye gram-negative, kusanganisira pathogenic organisms ari oga mukiriniki; komboni yacho yakaratidza kugadzikana kweasidhi, uye kuwedzerwa kweserum yemunhu kwakangove nemhedzisiro padiki inhibitory concentration (MIC) yezvipenyu zvinonzwa. Kana yakapihwa nemuromo kana pasi pasi kumhuka dzakatapukirwa kuyedza neakasiyana mabhakitiriya epathogenic, cephradine yakapa dziviriro inoshanda.[16]. Mukurapa kwezvirwere zvinotapukira, mhinduro dzekiriniki dzinogutsa kune cephradine therapy dzakataurwa nevanoverengeka vaongorori.[14, 15, 17-19].
