Tsanangudzo Pfupi
Nhamba yeCAS: 15687-27-1
Molecular formula: C13H18O2
Molecular uremu: 206.28
Kemikari chimiro:
| Basic Information | |
| Product name | Ibuprofen |
| CAS Nha. | 15687-27-1 |
| Color | Muchena kusvika kure-chena |
| Form | Crystalline Powder |
| Solubility | Inenge isinganyungudika mumvura, inonyungudika zvakasununguka muacetone, mumethanol uye mumethylene chloride. Iyo inonyunguduka mu dilute mhinduro dze alkali hydroxides uye carbonates. |
| Mvura Solubility | insoluble |
| Kugadzikana | Yakagadzikana. Inopisa. Hazvienderani neakasimba oxidizing agents |
| Sherufu Hupenyu | 2 Ynzeve |
| Package | 25kg/Drum |
Tsanangudzo
Ibuprofen ndeye isiri-steroidal anti-inflammatory analgesic. Iyo ine yakanakisa anti-kuzvimba, analgesic uye antipyretic mhedzisiro ine mashoma akashata maitiro. Yave kushandiswa zvakanyanya munyika, semishonga inotengeswa pasi rose isiri-yachiremba. Iyo, pamwe chete neaspirin uye paracetamol yakanyorwa seakakosha matatu antipyretic analgesics zvigadzirwa. Munyika yedu, inonyanya kushandiswa mukuderedza marwadzo uye anti-rheumatism, etc. Iine zvikumbiro zvishoma mukurapa kwechando nefivha kana ichienzaniswa neparacetamol uye aspirin. Kune akawanda emakambani emishonga anokodzera kugadzirwa kweibuprofen muChina. Asi iyo yakawanda yemusika wepamba yekutengesa ibuprofen yakagarwa neTianjin Sino-US Kambani.
Ibuprofen yakawanikwa pamwe chete naDr. Stewart Adams (gare gare anova purofesa uye akakunda Medal of the British Empire) neboka rake kusanganisira CoLinBurrows uye Dr. John Nicholson. Chinangwa chechidzidzo chekutanga chaive chekugadzira "super aspirin" kuti uwane imwe nzira yekurapa rheumatoid arthritis inofananidzwa neiyo aspirin asi ine zvishoma zvakakomba maitiro. Kune mamwe madhiragi akadai se phenylbutazone, ine ngozi yakawanda yekukonzera adrenal kudzvinyirira uye zvimwe zviitiko zvakashata zvakadai semaronda emudumbu. Adams akasarudza kutsvaga mushonga une gastrointestinal resistance, iyo inonyanya kukosha kune yose isiri-steroidal anti-inflammatory drugs.
Phenyl acetate mishonga yakamutsa kufarira kwevanhu. Kunyange zvazvo mamwe emishonga iyi akawanikwa ari pangozi yekukonzera maronda zvichienderana nekuongorora kwembwa, Adams anoziva kuti chiitiko ichi chinogona kunge chiri chikonzero chenguva yakareba hafu yeupenyu hwekuregererwa kwezvinodhaka. Mukirasi iyi yemishonga kune mubatanidzwa - ibuprofen, iyo ine zvishoma zvishoma hafu yeupenyu, inochengetedza maawa maviri chete. Pakati pemishonga yakaongororwa, kunyange zvazvo isiri iyo inonyanya kushanda, ndiyo yakachengeteka zvikuru. Muna 1964, ibuprofen yakanga yava imwe nzira inovimbisa zvikuru kune aspirin.
Zviratidzo
Chinangwa chakafanana mukugadzirwa kwemishonga yemarwadzo nekuzvimba kwave kugadzira kwemakemikari ane kugona kurapa kuzvimba, fivha, uye kurwadziwa pasina kukanganisa mamwe mabasa emuviri. General pain relievers, senge aspirin uye ibuprofen, inhibit zvese COX-1 uye COX-2. Kutsanangurwa kwemushonga kuCOX-1 maringe neCOX-2 kunotarisisa mukana wemhedzisiro yakaipa. Mishonga ine hunyanzvi hwakanangana neCOX-1 ichave nemukana wakakura wekugadzira mhedzisiro yakaipa. Nekudzima COX-1, marwadzo asingasarudze anowedzera mukana weasingadiwi mhedzisiro, kunyanya matambudziko ekugaya akadai semaronda emudumbu uye kubuda ropa kwemudumbu. COX-2 inhibitors, yakadai seVioxx uye Celebrex, inosarudza kubvisa COX-2 uye usakanganisa COX-1 pamiyero yakatarwa. COX-2 inhibitors inonyorerwa zvakanyanya arthritis uye kunyaradza kurwadziwa. Muna 2004, Food and Drug Administration (FDA) yakazivisa kuti kuwedzera kwengozi yekurwadziwa kwemoyo uye sitiroko yakabatana nemamwe COX-2 inhibitors. Izvi zvakaita kuti pave nemabhii ekunyevera uye nekuzvidira kubviswa kwezvinhu kubva pamusika nevagadziri vezvinodhaka; somuenzaniso, Merck akatora Vioxx kubva pamusika muna 2004. Kunyange zvazvo ibuprofen inhibits zvose COX-1 uye COX-2, ine kanoverengeka iyo yakananga kuCOX-2 kana ichienzaniswa neAspirin, ichigadzira zvishoma zvinokonzerwa nemudumbu..
