Tsanangudzo Pfupi
Nhamba yeCAS: 59-05-2
Molecular formula: C20H22N8O5
molecular uremu: 454.45
Kemikari chimiro:
| Basic Information | |
| Product name | Methotrexate |
| Giredhi | giredhi remishonga |
| Chitarisiko | orenji-yellow crystalline poda. |
| Assay | 99% |
| Sherufu hupenyu | 2 Makore |
| Packing | 25kg/katoni |
| Hunhu | Yakagadzikana, asi yakajeka inonzwisisika uye hygroscopic. Hazvienderani neakasimba acids, yakasimba oxidizing agents. |
| Condition | Ramba uri munzvimbo ine rima, Inert atmosphere, Chengetedza mufiriza, pasi pe -20°C |
Chii chinonzi Methotrexate?
Methotrexate inonzwa kune hydrolysis, oxidation uye chiedza. Insoluble mumvura. Methotrexate inoora mumamiriro ezvinhu ane acidic zvakanyanya kana alkaline. Methotrexate haienderani neakasimba oxidizing agents uye yakasimba acids.
Methotrexate mushonga unoshandiswa kurapa cancer, inozivikanwawo se cytotoxic zvinodhaka. Kuti uderedze cytotoxicity yayo, inogona kushandiswa pamwe chete ne calcium leucovorin. Inonyanya kushandiswa pakurapa acute leukemia (acute lymphocytic leukemia), kenza yemazamu, malignant mole uye choriocarcinoma, kenza yemusoro nemutsipa, kenza yemapfupa, leukemia, spinal cord meningeal infiltration, kenza yemapapu, kenza yekubereka, kenza yechiropa, refractory. psoriasis vulgaris, dermatomyositis, muviri myositis, ankylosing spondylitis kuzvimba, chirwere cheCrohn, psoriasis uye psoriatic arthritis, chirwere cheBehcet uye chirwere che autoimmune. Methotrexate is immuno suppressant uye inogona kushandiswa kurerutsa maitiro e rheumatism nehunyanzvi hwekuita mukurapa synovial kuzvimba kwerheumatoid arthritis uye ndiyo inonyanya kushandiswa mishonga yekurapa rheumatoid zvirwere.
Clinical application
Inoshanda mukurapa acute leukemia nekuita zviri nani muvarwere vevana. Iine hutano hwakanaka mukurapa choriocarcinoma uye yakaipa mole. Huru yedosi kutonga inoshanda mukurapa osteosarcoma, nyoro matishu sarcoma, kenza yemapapu, testicular cancer, kenza yemazamu, uye ovarian cancer. Inoshandawo mukurapa kenza yemusoro nemutsipa, kenza yechiropa uye kenza yemudumbu. Arterial infusion yechigadzirwa ichi ine goo efficacy mukurapa musoro negomarara remutsipa uye chiropa. Nekudaro, haiwanzo kushandiswa kurapa psoriasis uye psoriasis.
