Tsanangudzo Pfupi
Nhamba yeCAS:55268-74-1
Molecular formula:C19H24N2O2
molecular uremu:312.41
Kemikari chimiro:
| Basic Information | |
| Product name | Praziquantel |
| Giredhi | Pharma giredhi |
| Chitarisiko | Ichena kana inenge yakachena crystalline powder |
| Assay | 99% |
| Sherufu hupenyu | 2 years |
| Packing | 25kg / chigubhu |
| Hunhu | Yakasununguka soluble mu ethanol kana dichloromethane. Zvishoma soluble mumvura |
| Condition | Yakavharwa pakaoma,Chengeta mufiriji, pasi pe -20°C |
Tsanangudzo
Praziquantel (PZQ) inotorwa isoquinoline ine zvizhinji zvezviitwa zvebhayoloji zvinowanikwa mulevo enantiomer. Komboni yacho haina basa rekurwisa nematodes, asi inoshanda zvakanyanya pakurwisa cestodes uye trematodes.
Pharmacology uye nzira yekuita
Praziquantel mushonga wepyrazinoquinoline wakatanga kugadzirwa kuti urapwe schistosomiasis asi wakaonekwa uine huwandu hwakawanda hwekuita kweanthelminthic. Praziquantel inomhanya mhanya asi iyo R (+) enantiomer ndiyo inokonzeresa kuita kwayo antiparasitic. Inoshanda kurwisa trematodes (ese Schistosoma marudzi pathogenic kumunhu, Paragonimus westermani, uye Clonorchis sinensis) uye cestodes (Taenia saginata, Taenia solium, Hymenolepis nana uye Diphyllobothrium latum).
Maitiro ekuita kwepraziquantel haazivikanwe zvakajeka. Schistosomes inotora mushonga nekukurumidza. Kutora zvinodhaka kunokurumidza kuteverwa nekuwedzera kwetsandanyama chiitiko chinoenda kune tetanic contraction uye vacuolization yeparasite tegument.
Izvo tsandanyama zvinokonzerwa nemushonga zvinofungidzirwa kuti ndizvo zvinokonzeresa kuchinjika kwemaparasite kubva mutsinga mesenteric kuenda kuchiropa mu vivo. Nekudaro, kuchinja kwechiropa kwakaratidzwa neakawanda anozivikanwa schistosomicides uye inogona kusapa chero ruzivo rwemaitiro emushonga. Zvichangobva kuongororwa zvakawanikwa zvakaratidza kuti antischistosomal mhedzisiro yemushonga ine hukama nemhedzisiro yayo pane tegument kwete pane musculature.
Imwezve pharmacological mhedzisiro yemushonga inosanganisira kuwedzera kwe membrane permeability kune cations, kunyanya calcium.
Zvisinei, basa rechiitiko ichi kune anthelminthic pfuma yemushonga hazvizivikanwi.
Application
Imhando ye-broad-spectrum anti-parasitic chirwere mushonga. Inogona kushandiswa pakurapa uye kudzivirira schistosomiasis, cysticercosis, paragonimiasis, hydatid chirwere, fasciolopsiasis, hydatid chirwere, uye utachiona hwehonye.
Inogonawo kushandiswa seanthelmintic uye inoshanda mukurapa mhuka dzemudumbu nematodes. Inogona kusanganiswa mukudya kwekushandisa.
Chigadzirwa chacho imhando yemishonga yeanthelmintic inoshanda pakurapa Schistosoma japonicum, Schistosoma mansoni uye Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms uye cysticercosis. Iyo ine kuuraya kwakasimba zvakanyanya pane tapeworm uye parizvino inoshanda zvakanyanya pakati peanti-schistosomiasis mushonga.
Imhando yemishonga yeanthelmintics inonyanya kushandiswa kurapa schistosomiasis. Inogona zvakare kushandiswa kurapa Fahrenheit schistosomiasis, taeniasis, paragonimiasis, uye cysticercosis.
