Tsanangudzo Pfupi
Nhamba yeCAS:51322-75-9
Molecular formula:C9H8ClN5S
molecular uremu:253.71
Kemikari chimiro:
| Basic Information | |
| Product name | Tizanidine |
| Giredhi | Pharma giredhi |
| Chitarisiko | White Powder |
| Assay | 99% |
| Sherufu hupenyu | 2 years |
| Packing | 25kg / chigubhu |
| Condition | Chengetedza pa -20°C |
Outline
Tizanidine inonzi imidazoline maviri nitrogen heterocyclic pentene derivative. Chimiro chakafanana neiyo clonidine. Muna 1987, yakatanga kunyorwa muFinland sepakati adrenalin α2 receptor agonist. Parizvino, inoshandiswa sepakati mhasuru inozorodza mukiriniki. Inogona kushandiswa kurapa zvinorwadza tsandanyama spasm, senge neck waist syndrome uye torticollis. Inogonawo kushandiswa kurapa kurwadziwa kwepashure, senge disc herniation uye hip arthritis. Inobva kune ankylosis yehutano hwetsinga, senge multiple sclerosis, chisingaperi myelopathy, cerebrovascular tsaona uye nezvimwe.
Function
Inoshandiswa kuderedza skeletal muscle tension, muscle spasm uye myotonia inokonzerwa nehuropi uye musana wekukuvara kwemutsipa, cerebral hemorrhage, encephalitis uye multiple sclerosis.
Pharmacology
Iyo inosarudza inoderedza kuburitswa kweanofadza amino acids kubva kune interneurons uye inhibits iyo yakawanda synaptic michina ine chekuita nemhasuru overstrain. Ichi chigadzirwa hachikanganisi kutapurirana neuromuscular. Inoshivirirwa zvakanaka. Inoshanda kune zvakanyanya kurwadza kwemhasuru spasms uye chisingaperi ankylosis inotangira kubva kumusana uye uropi. Inogona kuderedza kushorwa kwekufamba kwekufamba, kuderedza spasticity uye clonus, uye kuwedzera kusimba kwekufamba kwekuzvidira.
Uses
Yakanyorwa Tizanidine, yakagadzirirwa kushandiswa seyemukati chiyero chekuyerwa kweTizanidine neGC- kana LC-mass spectrometry. Tizanidine inogona kuve nekushandiswa kwekurapa seSARS-CoV-2 main protease inhibitor.
Clinical Kushandisa
Tizanidine inonzi centrally acting adrenergic α2 receptor agonist inoshandiswa kurapa zvisingaperi tsandanyama spasticity mamiriro, akadai semultiple sclerosis.
Nzira yekuita
Tizanidine is a centrally active muscle relaxant analogue ye clonidine inotenderwa kuti ishandiswe mukuderedza spasticity ine chekuita necerebral kana spinal cord kukuvara. Maitiro ayo ekuita ekudzikisa spasticity anoratidza presynaptic inhibition yemota neurons paα2-adrenergic receptor nzvimbo, kuderedza kusunungurwa kwekunakidza amino acids uye inhibiting facilitatory ceruleospinal pathways, zvichiita kuti kuderedzwa kwepasticity. Tizanidine inongori nechikamu chidiki cheiyo antihypertensive chiito checlonidine, zvichida nekuda kwechiito pane boka rinosarudzwa reα2C-adrenoceptors, iyo inoratidzika kunge inokonzera analgesic uye antispasmodic basa re imidazolineα2-agonists(20).
