Tsanangudzo Pfupi
Nhamba yeCAS:590-63-6
Molecular formula:C7H17ClN2O2
molecular uremu:196.68
Kemikari chimiro:
| Basic Information | |
| Product name | Bethanechol |
| Giredhi | Pharma giredhi |
| Chitarisiko | hupfu chena |
| Assay | 95% |
| Sherufu hupenyu | 2 years |
| Packing | 25kg / chigubhu |
| Condition | Nzvimbo Inotonhorera uye Yakaoma |
Tsanangudzo
Bethanechol is synthetic ester yakarongeka uye pharmacologically inoenderana neacetylcholine. A zvishoma nezvishoma hydrolyzed muscarinic agonist isina nicotinic mhedzisiro, bethanechol inowanzoshandiswa kuwedzera yakatsetseka tsandanyama toni, senge muGI turakiti rinotevera kuvhiyiwa mudumbu kana mukuchengetedza weti mukusavapo kwekuvharira. Inogona kukonzera hypotension, chiyero chemoyo shanduko, uye bronchial spasms.
Bethanechol is anagonist of muscarinic acetylcholine receptors ine IC50 values ye1,837, 25, 631, 317, uye 393 μM yeM1-5, zvichiteerana, mune radioligand inosunga assay uchishandisa CHO masero anoratidza ma receptors evanhu. Inodzivisa M2-mediated kuwedzera mu cyclic AMP inokonzerwa ne isoproterenol mune imwe yega guinea yenguruve mudumbu muduku (IC50 = 127 μM). Bethanechol inowedzera basal toni yeyoga porcine intravesical ureter (EC50 = 4.27 μM). Inokonzerawo kuvharwa kwemvura muileum, duodenum, uye jejunum yemakonzo anesthetized kana ichishandiswa pachiyero che 60 μg / kg. Magadzirirwo ane bethanechol akashandiswa kuwedzera weti uye kunatsiridza tsandanyama toni mudumbu remudumbu.
Clinical Kushandisa
Kunyanya kushandiswa kwebethanechol chloride ndeyekuzorodza kwekuchengetedza weti uye dumbu rakaputika mushure mekuvhiyiwa. Mushonga unoshandiswa nemuromo uye nejekiseni rezasi. Haifanirwe kupihwa intramuscular kana intravenousjection nekuda kwenjodzi kubva kucholinergic overstimulation uye kurasikirwa kwesarudzo. Kudzora kwakaringana kwemushonga kwakabatana nekuderera muchetura uye hapana chakakomba mhedzisiro. Bethanechol chloride inofanira kushandiswa nekuchenjerera varwere vane asthmatic; kana ichishandiswa glaucoma, inoburitsa kurwadza kwemusoro kubva pakudzvanywa kwesphinctermuscle muziso uye kubva kune ciliary tsandanyama spasms. Nguva yekuita kwayo i1 awa.
Veterinary Drugs uye Kurapa
Mukurapa kwezvipfuyo, bethanechol inoshandiswa zvakanyanya kukurudzira kubatira dundira mumhuka diki. Iyo zvakare inogona kushandiswa sesophageal kana general GI stimulant, kunyangwe metoclopramide uye/ kana neostigmine vakanyanya kuitsiva kune izvi zvinoshandiswa.
